| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Anti-proliferative family proteins |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Tob1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
carcinogenesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inflammatory bowel disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ulcerative colitis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Crohn’s disease |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
池田 祐香
Taniguchi Kurumi
吉川 小百合
Sawamura Haruka
辻 愛
松田 覚
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| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exert a role of engrams for making the condition of specific inflammation in the gut. Dysregulation of immune cells induced by the command of engrams might be crucial in the pathogenesis of damages in gut epithelium. The anti-proliferative (APRO) family of anti-proliferative proteins characterized by immediate early responsive gene-products that might be involved in the machinery of the carcinogenesis in IBD. Herein, it is suggested that some probiotics with specific bacteria could prevent the development and/or progression of the IBD related tumors. In addition, consideration regarding the application of studying APRO family proteins for the comprehension of IBD related tumors has been presented. It is hypothesized that overexpression of Tob1, a member of APRO family proteins, in the epithelium of IBD could suppress the function of adjacent cytotoxic immune cells possibly via the paracrine signaling. |
|
言語 |
en |
| 書誌情報 |
en : Exploration of Medicine
巻 2,
号 3,
p. 468-478,
発行日 2022-10-27
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| 出版者 |
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|
出版者 |
Open Exploration |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2692-3106 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.37349/emed.2022.00108 |
| 権利 |
|
|
権利情報 |
© The Author(s) 2022. |
|
言語 |
en |
https://doi.org/10.37349/emed.2022.00108
