{"created":"2025-01-23T05:06:01.265365+00:00","id":2005867,"links":{},"metadata":{"_buckets":{"deposit":"17f1ef94-dc00-4521-a6cf-9bc0f8a81b24"},"_deposit":{"created_by":8,"id":"2005867","owner":"8","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2005867"},"status":"published"},"_oai":{"id":"oai:nara-wu.repo.nii.ac.jp:02005867","sets":["1708506446917:1708568814153:1708568841932"]},"author_link":[],"control_number":"2005867","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"478","bibliographicPageStart":"468","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Exploration of Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exert a role of engrams for making the condition of specific inflammation in the gut. Dysregulation of immune cells induced by the command of engrams might be crucial in the pathogenesis of damages in gut epithelium. The anti-proliferative (APRO) family of anti-proliferative proteins characterized by immediate early responsive gene-products that might be involved in the machinery of the carcinogenesis in IBD. Herein, it is suggested that some probiotics with specific bacteria could prevent the development and/or progression of the IBD related tumors. In addition, consideration regarding the application of studying APRO family proteins for the comprehension of IBD related tumors has been presented. It is hypothesized that overexpression of Tob1, a member of APRO family proteins, in the epithelium of IBD could suppress the function of adjacent cytotoxic immune cells possibly via the paracrine signaling.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Open Exploration","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.37349/emed.2022.00108","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2022.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2692-3106","subitem_source_identifier_type":"EISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikeda Yuka","creatorNameLang":"en"},{"creatorName":"池田 祐香","creatorNameLang":"ja"},{"creatorName":"いけだ ゆか","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Taniguchi Kurumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshikawa Sayuri","creatorNameLang":"en"},{"creatorName":"吉川 小百合","creatorNameLang":"ja"},{"creatorName":"よしかわ さゆり","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Sawamura Haruka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsuji Ai","creatorNameLang":"en"},{"creatorName":"辻 愛","creatorNameLang":"ja"},{"creatorName":"つじ あい","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Matsuda Satoru","creatorNameLang":"en"},{"creatorName":"松田 覚","creatorNameLang":"ja"},{"creatorName":"まつだ さとる","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1000050242110","nameIdentifierScheme":"KAKEN2","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050242110"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","fileDate":[{"fileDateType":"Available","fileDateValue":"2025-01-23"}],"url":{"objectType":"fulltext","url":"https://doi.org/10.37349/emed.2022.00108"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anti-proliferative family proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tob1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"carcinogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory bowel disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ulcerative colitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Crohn’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"8","path":["1708568841932"],"publish_date":"2025-01-23","publish_status":"0","recid":"2005867","relation_version_is_last":true,"title":["A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-02-18T07:40:39.248676+00:00"}