Roles of Ca2+ in hyphal and yeast-form growth in Candida albicans. Growth regulation by altered extracellular and intracellular free Ca2+ concentrations

Sakaguchi,Shuichi; さかぐち,しゅういち; 坂口,修一; Kyoko,Shibuya; しぶや,きょうこ; Hidetoshi,Iida; いいだ,ひでとし; Yasuhiro,Anraku; あんらく,やすひろ; Suzuki,Takahito; すずき,たかひと

doi:https://doi.org/10.1007/BF02460856

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Roles of Ca2+ in hyphal and yeast-form growth in Candida albicans. Growth regulation by altered extracellular and intracellular free Ca2+ concentrations

http://hdl.handle.net/10935/4590

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AA11632817V38pp215-225.pdf

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default_学術雑誌論文 / Journal Article(1)

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Roles of Ca2+ in hyphal and yeast-form growth in Candida albicans. Growth regulation by altered extracellular and intracellular free Ca2+ concentrations

言語

eng

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主題Scheme

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主題

calcium ion

キーワード

言語

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主題

cytokinesis

キーワード

言語

主題Scheme

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主題

fura-2

キーワード

言語

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probenecid

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言語

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主題

tip growth

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http://purl.org/coar/resource_type/c_6501

資源タイプ

journal article

著者

坂口,修一

kaken2 1000020221997

en	Sakaguchi,Shuichi
ja-Kana	さかぐち,しゅういち
ja	坂口,修一

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Abstract

内容記述

The dimorphic fungusCandida albicans has both a yeast form and a hyphal form. When yeast-form cells were starved and then transferred to aN-acetylglucosamine medium, the formation of true hyphae from the unbudded yeast-form cells was induced. Removal of Ca2+ from the medium with EGTA inhibited hyphal formation by 50%, resulting in only thin and short hyphae. Externally applied excess Ca2+ (>10-2M) also affected the hyphal formation, resulting in formation of pseudohyphae. This effect required a high concentration of Ca2+ but was Ca2+-specific. Deprivation of Ca2+ also inhibited yeast-form growth. Interestingly, such cells had abnormally wide bud necks and became defective in cell separation. To measure cytosolic free Ca2+, fura-2 was introduced into hyphal cells by electroporation. Its normal value was estimated to be about 100 nM. The electroporation caused transient elevation of cytosolic free Ca2+ concentration and transient cessation of hyphal growth. There was a close correlation between the timing of recovery of Ca2+ concentration and that of the resumption of hyphal growth. Our results demonstrate the importance of extracellular and intracellular free Ca2+ for the growth ofC. albicans.

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書誌情報

en : Mycoscience

巻 38, 号 2, p. 215-225, 発行日 1997-05-26

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Springer-Verlag

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収録物識別子

1340-3540

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NCID

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Roles of Ca2+ in hyphal and yeast-form growth in Candida albicans. Growth regulation by altered extracellular and intracellular free Ca2+ concentrations

× 坂口,修一

× Kyoko,Shibuya

× いいだ,ひでとし

× あんらく,やすひろ

× すずき,たかひと

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