| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Potential Molecular Mechanisms of Alcohol Use Disorder with Non-Coding RNAs and Gut Microbiota for the Development of Superior Therapeutic Application |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ncRNA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lncRNA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
miRNA |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
autophagy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gut microbiota |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gut-brain axis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alcohol dependence |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alcohol use disorder |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
中嶋, 萌香
菅, 尚子
吉川, 小百合
池田 祐香
松田, 覚
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Many investigations have evaluated the expression of noncoding RNAs (ncRNAs) as well as their related molecular functions and biological machineries in individuals with alcohol dependence. Alcohol dependence may be one of the most prevailing psychological disorders globally, and its pathogenesis is intricate and inadequately comprehended. There is substantial evidence indicating significant links between multiple genetic factors and the development of alcohol dependence. In particular, the critical roles of ncRNAs have been emphasized in the pathology of mental illnesses, probably including alcohol dependence. In the comprehension of the action of ncRNAs and their machineries of modification, furthermore, they have emerged as therapeutic targets for a variety of psychiatric illnesses, including alcohol dependence. It is worth mentioning that the dysregulated expression of ncRNAs has been regularly detected in individuals with alcohol dependence. An in-depth knowledge of the roles of ncRNAs and m6A modification may be valuable for the development of a novel treatment against alcohol dependence. In general, a more profound understanding of the practical roles of ncRNAs might make important contributions to the precise diagnosis and/or actual management of alcohol dependence. Here, in this review, we mostly focused on up-to-date knowledge regarding alterations and/or modifications in the expression of ncRNAs in individuals with alcohol dependence. Then, we present prospects for future research and therapeutic applications with a novel concept of the engram system. |
|
言語 |
en |
| bibliographic_information |
en : Genes
巻 15,
号 4,
p. 431,
発行日 2024
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| 出版者 |
|
|
出版者 |
MDPI AG |
|
言語 |
en |
| item_10001_source_id_9 |
|
|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2073-4425 |
| item_10001_relation_14 |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.3390/genes15040431 |
| 権利 |
|
|
権利情報 |
© by the authors |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
https://doi.org/10.3390/genes15040431
