| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Poly(ADP-ribose) polymerase 1 (PARP1) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
reactive oxygen species |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ageing |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
progeroid syndrome |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Werner syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bloom syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cockayne syndrome |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
菅 尚子
Ikeda Yuka
Yoshikawa Sayuri
Matsuda Satoru
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford progeria syndrome, and Cockayne syndrome. These disorders may also exhibit some pathological involvements reminiscent of primary mitochondrial diseases. Emerging evidence has linked mitochondria even to physiological ageing. In addition, alterations in the maintenance pathway of mitochondria have been also deliberated as relevant in age-related diseases. In particular, mitophagy and its regulatory pathway might be key process for the homeostasis of mitochondria. Therefore, chronic DNA damage and/or the activation of poly[adenosine diphosphate (ADP)-ribose] polymerase 1 (PARP1) could be a threat to the mitochondrial alterations. The PARP1 is an enzyme responding to the DNA damage, which might be also involved in the mitophagy. Interestingly, the PARP1 has been reported to play an important role in the longevity of lifespan, which has attracted growing attention with the social development. This review may provide a rationalized overview of the involvement of mitochondrial oxidative stresses in genetically defined accelerated ageing, progeroid syndromes, physiological ageing, and/or age-related diseases for the innovative therapeutic approaches. |
|
言語 |
en |
| bibliographic_information |
en : Exploration of Medicine
p. 822-838,
発行日 2023
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| 出版者 |
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出版者 |
Open Exploration Publishing Inc. |
|
言語 |
en |
| item_10001_source_id_9 |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2766-2098 |
| item_10001_relation_14 |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.37349/emed.2023.00180 |
| 権利 |
|
|
権利情報 |
© The Author(s) |
|
言語 |
en |
https://doi.org/10.37349/emed.2023.00180
