| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Inspiring Tactics with the Improvement of Mitophagy and Redox Balance for the Development of Innovative Treatment against Polycystic Kidney Disease |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
polycystic kidney disease |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
chronic kidney disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
autophagy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mitophagy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mitochondria |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hypoxia |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adenosine monophosphate-activated protein kinase |
| キーワード |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gut microbiome |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
Nakashima Moeka
菅 尚子
池田 祐香
Yoshikawa Sayuri
Matsuda Satoru
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Polycystic kidney disease (PKD) is the most common genetic form of chronic kidney disease (CKD), and it involves the development of multiple kidney cysts. Not enough medical breakthroughs have been made against PKD, a condition which features regional hypoxia and activation of the hypoxia-inducible factor (HIF) pathway. The following pathology of CKD can severely instigate kidney damage and/or renal failure. Significant evidence verifies an imperative role for mitophagy in normal kidney physiology and the pathology of CKD and/or PKD. Mitophagy serves as important component of mitochondrial quality control by removing impaired/dysfunctional mitochondria from the cell to warrant redox homeostasis and sustain cell viability. Interestingly, treatment with the peroxisome proliferator-activated receptor-α (PPAR-α) agonist could reduce the pathology of PDK and might improve the renal function of the disease via the modulation of mitophagy, as well as the condition of gut microbiome. Suitable modulation of mitophagy might be a favorable tactic for the prevention and/or treatment of kidney diseases such as PKD and CKD. |
|
言語 |
en |
| bibliographic_information |
en : Biomolecules
巻 14,
号 2,
p. 207,
発行日 2024-02-09
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| item_10001_source_id_9 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2218-273X |
| item_10001_relation_14 |
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識別子タイプ |
DOI |
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関連識別子 |
10.3390/biom14020207 |
| 権利 |
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|
権利情報 |
© by the authors |
|
言語 |
en |
https://doi.org/10.3390/biom14020207
