| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Diagnostic markers |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Fluorescent probes |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
Wang, Mengfei
Kono, Masaya
Yamaguchi, Yusaku
Islam, Jahidul
Shoji, Sunao
Kitagawa, Yuichi
Fushimi, Koji
Watanabe, Sora
Matsuba, Go
Yamamoto, Akihisa
Tanaka, Motomu
Tsuda, Masumi
Tanaka, Shinya
Hasegawa, Yasuchika
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Accurate determination of human tumor malignancy is important for choosing efficient and safe therapies. Bioimaging technologies based on luminescent molecules are widely used to localize and distinguish active tumor cells. Here, we report a human cancer grade probing system (GPS) using a water-soluble and structure-changeable Eu(III) complex for the continuous detection of early human brain tumors of different malignancy grades. Time-dependent emission spectra of the Eu(III) complexes in various types of tumor cells were recorded. The radiative rate constants (kr), which depend on the geometry of the Eu(III) complex, were calculated from the emission spectra. The tendency of the kr values to vary depended on the tumor cells at different malignancy grades. Between T = 0 and T = 3 h of invasion, the kr values exhibited an increase of 4% in NHA/TS (benign grade II gliomas), 7% in NHA/TSR (malignant grade III gliomas), and 27% in NHA/TSRA (malignant grade IV gliomas). Tumor cells with high-grade malignancy exhibited a rapid upward trend in kr values. The cancer GPS employs Eu(III) emissions to provide a new diagnostic method for determining human brain tumor malignancy. |
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言語 |
en |
| bibliographic_information |
en : Scientific Reports
巻 14,
号 1,
p. 778-1-778-8,
ページ数 8,
発行日 2024-01-22
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| 出版者 |
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出版者 |
Springer Nature |
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言語 |
en |
| item_10001_source_id_9 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
| item_10001_relation_14 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-023-50138-9 |
| 権利 |
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権利情報 |
© The Author(s) |
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言語 |
en |
| 出版タイプ |
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出版タイプ |
NA |
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出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
Publiser Site
