| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
OLA1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Centrosome amplification |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Estrogen |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Tumor suppressor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BRCA1 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
Yoshino Yuki
Ogoh Honami
Iichi Yudai
Sasaki Tomohiro
Yoshida Takahiro
Ichimura Shiori
Nakayama Masahiro
Xi Wu
Fujita Hiroki
Kikuchi Megumi
Fang Zhenzhou
Li Xingming
Abe Takaya
Futakuchi Mitsuru
Nakamura Yasuhiro
渡邊 利雄
Chiba Natsuko
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Obg-like ATPase 1 (OLA1) is a binding protein of Breast cancer gene 1 (BRCA1), germline pathogenic variants of which cause hereditary breast cancer. Cancer-associated variants of BRCA1 and OLA1 are deficient in the regulation of centrosome number. Although OLA1 might function as a tumor suppressor, the relevance of OLA1 deficiency to carcinogenesis is unclear. Here, we generated Ola1 knockout mice. Aged female Ola1+/− mice developed lymphoproliferative diseases, including malignant lymphoma. The lymphoma tissues had low expression of Ola1 and an increase in the number of cells with centrosome amplification. Interestingly, the proportion of cells with centrosome amplification in normal spleen from Ola1+/− mice was higher in male mice than in female mice. In human cells, estrogen stimulation attenuated centrosome amplification induced by OLA1 knockdown. Previous reports indicate that prominent centrosome amplification causes cell death but does not promote tumorigenesis. Thus, in the current study, the mild centrosome amplification observed under estrogen stimulation in Ola1+/− female mice is likely more tumorigenic than the prominent centrosome amplification observed in Ola1+/− male mice. Our findings provide a possible sex-dependent mechanism of the tumor suppressor function of OLA1. |
|
言語 |
en |
| 書誌情報 |
en : Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
巻 1870,
号 5,
p. 167138,
発行日 2024
|
| 出版者 |
|
|
出版者 |
Elsevier BV |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0925-4439 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.bbadis.2024.167138 |
| 権利 |
|
|
権利情報 |
© The Author(s) |
|
言語 |
en |
https://doi.org/10.1016/j.bbadis.2024.167138
