| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Endogenous Androgens Diminish Food Intake and Activation of Orexin A Neurons in Response to Reduced Glucose Availability in Male Rats |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
orchiectomy |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
feeding behavior |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
testosterone |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
orexin |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
lateral hypothalamic area |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
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主題 |
perifornical area |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
arcuate nucleus |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
glucoprivation |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
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主題 |
glucose availability |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
2-deoxy-d-glucose |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
鷹股 亮
Nishimura Yuri
Oka Ayano
Nagata Mayuna
Kosugi Natsumi
Eguchi Sayaka
根岸 裕子
森本 恵子
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Sex steroids modify feeding behavior and body weight regulation, and androgen reportedly augments food intake and body weight gain. To elucidate the role of endogenous androgens in the feeding regulation induced by reduced glucose availability, we examined the effect of gonadectomy (orchiectomy) on food intake and orexin A neuron’s activity in the lateral hypothalamic/perifornical area (LH/PFA) in response to reduced glucose availability (glucoprivation) induced by 2-deoxy-d-glucose (2DG) administration in male rats. Rats (7W) were bilaterally orchiectomized (ORX group) or sham operated (Sham group). Seventeen days after the surgery, food intake response to 2DG (400 mg/kg, i.v.) was measured for 4 h after the infusion. The same experiment was performed for the immunohistochemical examination of c-Fos-expressing orexin A neurons in the LH/PFA and c-Fos expression in the arcuate nucleus (Arc). Food intake induced by glucoprivation was greater in the ORX group than the Sham group, and the glucoprivation-induced food intake was inversely correlated with plasma testosterone concentration. Glucoprivation stimulated c-Fos expression of the orexin A neurons at the LH/PFA and c-Fos expression in the dorsomedial Arc. The number and percentage of c-Fos-expressing orexin A neurons in the LH/PFA and c-Fos expression in the dorsomedial Arc were significantly higher in the ORX group than the Sham group. This indicates that endogenous androgen, possibly testosterone, diminishes the food intake induced by reduced glucose availability, possibly via the attenuated activity of orexin A neuron in the LH/PFA and neurons in the dorsomedial Arc. |
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言語 |
en |
| 書誌情報 |
en : Nutrients
巻 14,
号 6,
p. 1235,
発行日 2022
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| 出版者 |
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出版者 |
MDPI AG |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2072-6643 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.3390/nu14061235 |
| 権利 |
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権利情報 |
© by the authors |
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言語 |
en |
https://doi.org/10.3390/nu14061235
