| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Encouraging probiotics for the prevention and treatment of immune-related adverse events in novel immunotherapies against malignant glioma |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glioma |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
oncolytic virus therapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immune-related adverse events |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gut microbiota |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gut-brain-immune axis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
engram |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immune-related disorders |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
reactive oxygen species |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
Yoshikawa Sayuri
Taniguchi Kurumi
Sawamura Haruka
池田 祐香
辻 愛
松田 覚
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Among the malignant tumors in the central nervous system (CNS), glioma is the most challenging tumor to the public society, which accounts for the majority of intracranial malignant tumors with impaired brain function. In general, conventional therapies are still unable to provide an effective cure. However, novel immunotherapies have changed the treatment scene giving patients a greater potential to attain long term survival, improved quality of life. Having shown favorable results in solid tumors, those therapies are now at a cancer research hotspot, which could even shrink the growth of glioma cells without causing severe complications. However, it is important to recognize that the therapy may be occasionally associated with noteworthy adverse action called immune-related adverse events (IRAEs) which have emerged as a potential limitation of the therapy. Multiple classes of mediators have been developed to enhance the ability of immune system to target malignant tumors including glioma but may also be associated with the IRAEs. In addition, it is probable that it would take long time after the therapy to exhibit severe immune-related disorders. Gut microbiota could play an integral role in optimal immune development and/or appropriate function for the cancer therapy, which is a vital component of the multidirectional communication between immune system, brain, and gut, also known as gut-brain-immune axis. Here, we show the potential effects of the gut-brain-immune axis based on an “engram theory” for the innovative treatment of IRAEs. |
|
言語 |
en |
| 書誌情報 |
en : Exploration of Targeted Anti-tumor Therapy
p. 817-827,
発行日 2022
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| 出版者 |
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出版者 |
Open Exploration Publishing Inc. |
|
言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2692-3114 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.37349/etat.2022.00114 |
| 権利 |
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|
権利情報 |
© The Author(s) |
|
言語 |
en |
https://doi.org/10.37349/etat.2022.00114
