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Arf1 facilitates mast cell proliferation via the mTORC1 pathway
http://hdl.handle.net/10935/0002005883
http://hdl.handle.net/10935/00020058830059ebdc-c0bd-48e0-b802-c83feb8eb8aa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
https://doi.org/10.1038/s41598-022-26925-1
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| アイテムタイプ | default_学術雑誌論文 / Journal Article(1) | |||||||||||||
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| タイトル | ||||||||||||||
| タイトル | Arf1 facilitates mast cell proliferation via the mTORC1 pathway | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | metadata only access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||||
| 著者 |
小谷, 唯
× 小谷, 唯× 住吉, 麻実× Sasada, Megumi
× 渡邊, 利雄× 松田, 達志
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Mast cells are one of major players in allergic responses. Mast cell activation via the high affinity IgE receptor (FcεRI) causes degranulation and release of de novo synthesized proinflammatory cytokines in a process that involves vesicle trafficking. Considering that the GTPase ADP-ribosylation factor 1 (Arf1) orchestrates and maintains membrane traffic and organelle structure, it seems likely that Arf1 contributes to mast cell activation. Actually, it has been reported that pharmaceutical blockade of the Arf1 pathway suppresses cytokine secretion and mast cell degranulation. However, physiological roles of Arf1 in mast cells remain elusive. Here, by using a genetic approach, we demonstrate that Arf1 is required for optimal mTORC1 activation upon IL-3 and facilitates mast cell proliferation. On the other hand, contrary to our expectation, Arf1-deficiency had little impact on FcεRI-induced degranulation nor cytokine secretion. Our findings reveal an unexpected role of Arf1 in mast cell expansion and its potential as a therapeutic target in the mast cell proliferative disorders. | |||||||||||||
| 言語 | en | |||||||||||||
| bibliographic_information |
en : Scientific Reports 巻 12, 号 1, p. 22297, 発行日 2022-12-24 |
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| 出版者 | ||||||||||||||
| 出版者 | Scientific Reports | |||||||||||||
| 言語 | en | |||||||||||||
| item_10001_source_id_9 | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||||
| item_10001_relation_14 | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-022-26925-1 | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | (C)Author(s) | |||||||||||||
| 言語 | en | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | NA | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||||||
