| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Tactics with Prebiotics for the Treatment of Metabolic Dysfunction-Associated Fatty Liver Disease via the Improvement of Mitophagy |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
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主題Scheme |
Other |
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主題 |
prebiotics |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
NAFLD |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
MAFLD |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mitophagy |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ROS |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mTOR |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
AMPK |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PI3K/AKT signaling pathway |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Tsuji Ai
Yoshikawa Sayuri
Ikeda Yuka
Taniguchi Kurumi
Sawamura Haruka
Morikawa Sae
Nakashima Moeka
Asai Tomoko
松田 覚
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Mitophagy/autophagy plays a protective role in various forms of liver damage, by renovating cellular metabolism linking to sustain liver homeostasis. A characterized pathway for mitophagy is the phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)/Parkin-dependent signaling pathway. In particular, PINK1-mediated mitophagy could play an indispensable role in improving the metabolic dysfunction-associated fatty liver disease (MAFLD) which could precede to steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. In addition, the PI3K/AKT/mTOR pathway might regulate the various characteristics of cellular homeostasis including energy metabolism, cell proliferation, and/or cell protection. Therefore, targeting mitophagy with the alteration of PI3K/AKT/mTOR or PINK1/Parkin-dependent signaling to eliminate impaired mitochondria might be an attractive strategy for the treatment of MAFLD. In particular, the efficacy of prebiotics for the treatment of MAFLD has been suggested to be useful via the modulation of the PI3K/AKT/mTOR/AMPK pathway. Additionally, several edible phytochemicals could activate mitophagy for the improvement of mitochondrial damages, which could also be a promising option to treat MAFLD with providing liver protection. Here, the potential therapeutics with several phytochemicals has been discussed for the treatment of MAFLD. Tactics with a viewpoint of prospective probiotics might contribute to the development of therapeutic interventions. |
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言語 |
en |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 24,
号 6,
p. 5465
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1422-0067 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/ijms24065465 |
| 権利 |
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|
権利情報 |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. |
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言語 |
en |
| 権利 |
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|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Creative Commons Attribution 4.0 International |
|
言語 |
en |
https://doi.org/10.3390/ijms24065465
