WEKO3
インデックスリンク
アイテム
The transcription factor unc-130/FOXD3/4 contributes to the biphasic calcium response required to optimize avoidance behavior
http://hdl.handle.net/10935/0002005848
http://hdl.handle.net/10935/0002005848cb8b4e8a-3207-4d2a-b63b-fcde9ff56c7d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
https://doi.org/10.1038/s41598-022-05942-0
|
|
| アイテムタイプ | default_学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| タイトル | ||||||||
| タイトル | The transcription factor unc-130/FOXD3/4 contributes to the biphasic calcium response required to optimize avoidance behavior | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Genetics of the nervous system | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Neural circuits | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
堀 沙耶香
× 堀 沙耶香× Mitani Shohei
|
|||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The central neural network optimizes avoidance behavior depending on the nociceptive stimulation intensity and is essential for survival. How the property of hub neurons that enables the selection of behaviors is genetically defined is not well understood. We show that the transcription factor unc-130, a human FOXD3/4 ortholog, is required to optimize avoidance behavior depending on stimulus strength in Caenorhabditis elegans. unc-130 is necessary for both ON responses (calcium decreases) and OFF responses (calcium increases) in AIBs, central neurons of avoidance optimization. Ablation of predicted upstream inhibitory neurons reduces the frequency of turn behavior, suggesting that optimization needs both calcium responses. At the molecular level, unc-130 upregulates the expression of at least three genes: nca-2, a homolog of the vertebrate cation leak channel NALCN; glr-1, an AMPA-type glutamate receptor; and eat-4, a hypothetical L-glutamate transmembrane transporter in the central neurons of optimization. unc-130 shows more limited regulation in optimizing behavior than an atonal homolog lin-32, and unc-130 and lin-32 appear to act in parallel molecular pathways. Our findings suggest that unc-130 is required for the establishment of some AIB identities to optimize avoidance behavior. | |||||||
| 言語 | en | |||||||
| 書誌情報 |
en : Scientific Reports 巻 12, 号 1 |
|||||||
| 出版者 | ||||||||
| 出版者 | Springer Science and Business Media LLC | |||||||
| 言語 | en | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 20452322 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1038/s41598-022-05942-0 | |||||||
| 権利 | ||||||||
| 権利情報 | ©The Author(s) 2022 | |||||||
| 言語 | en | |||||||
| 権利 | ||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||
| 権利情報 | Creative Commons Attribution 4.0 International | |||||||
| 言語 | en | |||||||
