| アイテムタイプ |
default_学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
tryptophan |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
kynurenine |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immune-related disease |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
engram |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gut–brain axis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
gut microbiota |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inflammation |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
reactive oxygen species |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
辻 愛
Ikeda Yuka
Yoshikawa Sayuri
Taniguchi Kurumi
Sawamura Haruka
Morikawa Sae
Nakashima Moeka
Asai Tomoko
松田 覚
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, and immune systems, as well as in the development of inflammatory diseases. It has been documented that some kynurenine metabolites are considered to have anti-oxidative, anti-inflammatory, and/or neuroprotective properties. Importantly, many of these kynurenine metabolites may possess immune-regulatory properties that could alleviate the inflammation response. The abnormal activation of the tryptophan and kynurenine pathway might be involved in the pathophysiological process of various immune-related diseases, such as inflammatory bowel disease, cardiovascular disease, osteoporosis, and/or polycystic ovary syndrome. Interestingly, kynurenine metabolites may be involved in the brain memory system and/or intricate immunity via the modulation of glial function. In the further deliberation of this concept with engram, the roles of gut microbiota could lead to the development of remarkable treatments for the prevention of and/or the therapeutics for various intractable immune-related diseases. |
|
言語 |
en |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 24,
号 6,
p. 5742,
発行日 2023-03-22
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| 出版者 |
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出版者 |
MDPI |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1422-0067 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3390/ijms24065742 |
| 権利 |
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|
権利情報 |
© 2023 by the authors. Licensee MDPI |
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言語 |
en |
| 権利 |
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|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Creative Commons Attribution 4.0 International |
|
言語 |
en |
https://doi.org/10.3390/ijms24065742
