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インデックスリンク
アイテム
健康保持増進への寄与が期待できる精油成分の機能性評価
http://hdl.handle.net/10935/3755
http://hdl.handle.net/10935/3755918ad05a-f9d7-4e6b-a83d-4fcafe898655
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TheJapanFoodChemicalResearchFoundationAnnualReportV19pp32-36.pdf
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| アイテムタイプ | default_学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| タイトル | ||||||
| タイトル | 健康保持増進への寄与が期待できる精油成分の機能性評価 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | 健康保持促進 | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| 主題 | 精油成分 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | Functional evaluation of essential oils-derived chemicals for health promotion | |||||
| 言語 | en | |||||
| 著者 |
井上,裕康
× 井上,裕康× 中田,理恵子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis. Peroxisome proliferator-activated receptors (PPARs) are liganddependent transcription factors belonging to the nuclear receptor superfamily and are involved in the control of COX-2 expression, and vice versa. Several natural chemicals such as resveratrol have been identified as suppressors of COX-2 expression and activators of PPARs. These two properties targeted to COX-2 and PPARs will be useful in evaluating functional food components against lifestyle-related diseases. In this study, we evaluated spice essential oils using our established assays for COX-2 and PPARs. We found that spice essential oils derived from cinnamon bark, caraway seed, cinnamon leaf, cumin and cardamom suppress COX-2 promoter activity, and activate PPARα, β/δand γ, in cell-based transfection assays using bovine arterial endothelial cells. Moreover, from cinnamon bark oil, we identified trans-cinnamaldehyde as a major component of the suppressor of COX-2 expression and an activator of PPARα, β/δ and γ. PPARγ dependent suppression of COX-2 promoter activity was observed in response to trans-cinnamaldehyde treatment. These results may be important for understanding the anti-inflammatory and anti-lifestyle-related disease properties of trans-cinnamaldehyde. | |||||
| 言語 | en | |||||
| 書誌情報 |
ja : 日本食品化学研究振興財団第19回研究成果報告書 巻 19, p. 32-36, 発行日 2013 |
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| 出版者 | ||||||
| 出版者 | 日本食品化学研究振興財団 | |||||
| 言語 | ja | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
